|
Candidiasis, Familial, 2
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Deep dermatophytosis and inherited CARD9 deficiency.
|
24131138 |
2013 |
|
Candidiasis, Familial, 2
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
A homozygous CARD9 mutation in a family with susceptibility to fungal infections.
|
19864672 |
2009 |
|
Candidiasis, Familial, 2
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Crohn Disease
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
The CARD9 and CARD10 gene expression was significantly higher in UC groups compared with CD (<i>P <</i> 0.001).
|
30008619 |
2018 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
The latter activity, which promotes Card9 phosphorylation, links pVHL to control of NF-kappaB activity and tumorigenesis.
|
17936701 |
2007 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
CARD9 deletion changes the gut microbial landscape, suggesting that SYK-CARD9 signaling maintains a microbial ecology that promotes inflammasome activation and thereby restrains colitis and colon tumorigenesis.
|
30231985 |
2018 |
|
B-Cell Lymphomas
|
0.020 |
AlteredExpression
|
group |
BEFREE |
HFD activated p38 MAPK and increased expression of B-cell lymphoma/CLL 10 (BCL10) and caspase recruitment domain family member 9 (CARD9).
|
28158919 |
2017 |
|
Candidemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Thus, Dok3 suppresses Card9 signaling, and disrupting Dok3-Card9 interaction or inhibiting PP1 activity represents therapeutic opportunities to develop drugs to combat candidaemia.
|
31180338 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Caspase recruitment domain-containing protein 9 was upregulated in both OSCC tissues and cells, exhibiting a close relation with major clinicopathological features of OSCC patients.
|
31306536 |
2019 |
|
Lupus Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Murine kidney showed higher DAP-12, Syk, Card-9 and Dectin-1 mRNA expression during the progression of lupus nephritis.
|
22949850 |
2012 |
|
Pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CARD9 was overexpressed in SAP rats, which correlated with the severity of pancreatitis.
|
27957800 |
2017 |
|
Renal fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tim3, DAP-12, Card-9, DC-SIGN and MR2 were further up-regulated during renal fibrosis.
|
22949850 |
2012 |
|
Zinc deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Administration of SB203580 to HFD mice or specific siRNA in palmitate-treated cardiomyocytes eliminated the HFD and zinc deficiency activation of p38 MAPK, but did not significantly impact the expression of BCL10 and CARD9.
|
28158919 |
2017 |
|
Candidiasis, Familial, 2
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Deep dermatophytosis and inherited CARD9 deficiency.
|
24131138 |
2013 |
|
Candidiasis, Familial, 2
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Taken together, small molecules targeting CARD9 illustrate a path toward improved IBD therapeutics.
|
29073062 |
2017 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
This review summarizes recent insights into the regulation of CARD9 signaling, its pathophysiological role during IBD development via effects on the microbiota and epithelial regeneration and the pro- and antitumor immune functions of CARD9 during intestinal carcinogenesis.
|
30906296 |
2019 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Here, we used a rare CARD9 variant that confers protection against inflammatory bowel disease as an entry point to investigating CARD9 regulation.
|
26488816 |
2015 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
In this review, we provide mechanistic insights into the role of the CARD9 adaptor molecule in intestinal inflammation and determine a potential CARD9-targeting therapeutic approach against IBD.
|
31696662 |
2020 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Many more than expected by chance overlapped with genes previously implicated as playing a role in IBD susceptibility in genome-wide association scans, including CARD9, ICAM3, and IL8RB (P < 0.001).
|
22419656 |
2012 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Given that Lyn-deficient (<i>Lyn<sup>-/-</sup>)</i> mice are susceptible to both autoimmunity and IBD, we investigated the immunological role of CARD9 in the development of these diseases using the <i>Lyn<sup>-/-</sup></i> mouse model.
|
31594855 |
2019 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Upon activation, dectin-1 signaling converges, similar to NOD2, on the adaptor molecule CARD9 which is associated with inflammatory bowel disease (IBD).
|
19915667 |
2009 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
CTD_human |
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
|
21983784 |
2011 |
|
Ankylosing spondylitis
|
0.440 |
Biomarker
|
disease |
CTD_human |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
|
Ankylosing spondylitis
|
0.440 |
Biomarker
|
disease |
BEFREE |
CARD9 is a plausible candidate for AS given its central role in the innate immune response.
|
20463747 |
2010 |